Author: Frank Domino, MD in collaboration with Aylin Madore, MD

I stay up-to-date on the latest COVID-19 news and am regularly compiling a list of articles published that are relevant to your primary care practice. Read the insights below from recently published articles in less than two minutes.

Vitamin D Sufficiency, a Serum 25-Hydroxyvitamin D at Least 30 ng/mL Reduced Risk for Adverse Clinical Outcomes in Patients with COVID-19 Infection

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Observational study of 235 patients with COVID-19 admitted to the hospital in Iran found 20% of patients over 40 years of age had insufficient vitamin D levels (<30 ng/mL) on admission and approximately 90% of patients who died had insufficient levels. The authors noted that having a sufficient serum vitamin D level may lead to lower levels of C-reactive protein, and higher total blood lymphocyte count, theorizing higher vitamin D levels resulted in improved the immune function.

Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients with COVID-19 in Guangzhou, China

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Data from a prospective cohort study in China of 3410 close contacts of COVID-19 index-cases resulted in a 3.7% of developing the infection. Secondary attack rate for exposure was highest among household contacts (10.3%); lesser attack rate was noted for other exposures: 0.1% from public transportation, 1.0% healthcare workers, and 1.3% work exposure. The study also found that the greater the severity of the index-case was linked with the greater the risk of transmission (0.3% in contacts of asymptomatic cases vs 6.2% in contacts of severe/critical cases).

Alternations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

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One single factor that distinguishes COVID-19 from Influenza is the loss of sensation of Taste and Smell (seen in up to 60% of patients based upon observational data from Italy.

Loss of Anti-SARS-CoV-2 Antibodies in Mild COVID-19

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There remains conflicting data on persistence of antibody response in those already infected with the virus, with some showing loss of antibodies within a few weeks, while others show persistence up to 120 days after infection.

For more insights, view our collection of COVID-19 resources and CME courses. We recognize it is critical that you have access to timely, reliable information, so we are working hard to release new content in collaboration with our team of infectious disease experts, medical specialists, and primary care clinicians like Dr. Frank Domino.