Author: Frank Domino, MD in collaboration with Aylin Madore, MD

I stay up-to-date on the latest COVID-19 news and am regularly compiling a list of articles published that are relevant to your primary care practice. Read the insights below from recently published articles in less than two minutes.

CDC Contract Tracing

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The CDC redefined “close contact” as being within 6 feet of an infected person for at least 15 minutes over a 24-hour period beginning 2 days before symptom onset (or 2 days before testing in asymptomatic patients). Previously, the 15-minute exposure window was continuous.

FDA Approved First Treatment for COVID-19

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Despite the SOLIDARITY data, the US FDA voted to approve remdesivir for use in COVID-19 patients who require hospitalization and are at least 40 kg in weight.

Famotidine Use Is Not Associated with 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized COVID-19 Patients from a Large Healthcare System

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A post hoc analysis of in-hospital use of famotidine did not find a mortality benefit compared to non-use. It was unclear if pre-hospital famotidine use had any influence of COVID-19 mortality.

Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19

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A retrospective, observational cohort study of patients receiving aspirin within 24 hours of admission or those taking aspirin 7 days prior to admission (believed to be for ASCVD prophylaxis) found, after adjusting for confounding variables, aspirin use was associated with decreased risk of mechanical ventilation, ICU admission, and in-hospital mortality. There were no differences in major bleeding or overt thrombosis between aspirin users and non-aspirin users. Aspirin was started at time of admission, median dose was 81mg, and median treatment duration was 6 days. Despite the improved outcomes, patients who received aspirin had significantly higher pre-COVID rates of hypertension, diabetes mellitus, coronary artery disease, and renal disease.

Convalescent Plasma in the Management of Moderate COVID-19 in Adults in India: Open Label Phase II Multicentre Randomized Controlled Trial (PLACID Trial)

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A randomized, controlled study of almost 500 patients in India evaluated convalescent plasma vs not in addition to the standard of care found progression to severe disease or all-cause mortality within 28 days was ~18% in all patients, regardless of receiving plasma. Those in the intervention arm did have a higher conversion to a negative SARS-CoV-2 RNA test result on day 7, demonstrating efficacy of clearing the virus, but no impact on clinical outcomes.

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