Author: Frank Domino, MD in collaboration with Aylin Madore, MD

I stay up-to-date on the latest COVID-19 news and am regularly compiling a list of articles published that are relevant to your primary care practice. Read the insights below from recently published articles in less than two minutes.

Currently there are multiple COVID-19 vaccines in development reporting successful outcomes:

Moderna Announces Primary Efficacy Analysis in Phase 3 COVE Study For Its COVID-19 Vaccine Candidate and Filing Today with U.S. FDA for Emergency Use Authorization

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Moderna, Inc. reports approaching adequate enrollment of their vaccine. Their Phase 3 study included >7,000 Americans over the age of 65 and >5,000 Americans under 65 with high-risk chronic diseases (diabetes, severe obesity and cardiac disease). Reports find a 94.1% efficacy with a “100% efficacy at preventing severe illness”.

Pfizer and BioNTech Conclude Phase 3 Study of COVID-19 Vaccine Candidate, Meeting All Primary Efficacy Endpoints

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The Pfizer and BioNTech SARS-CoV-2 vaccine has demonstrated an efficacy >90% at 7 days after the second dose is given, based upon a phase 3 trial of ~44,000 volunteers (55). Pfizer reports a “95% efficacy”.

After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine

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The vaccine developed jointly by the University of Oxford and AstraZeneca is described in last week’s posting. However, there is now controversy regarding their data, as some irregularities were reported that may hinder its approval by the FDA.

A Living WHO Guideline on Drugs for COVID-19

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The World Health Organization recommends AGAINST Remdesivir for any form of SARS-CoV-2.

For more insights, view our collection of COVID-19 resources and CME courses. We recognize it is critical that you have access to timely, reliable information, so we are working hard to release new content in collaboration with our team of infectious disease experts, medical specialists, and primary care clinicians like Dr. Frank Domino.